![]() ![]() Having children after a tummy tuck tends to alter or “undo” the final results, and you may be left with additional excess skin and/or stubborn fat following your pregnancy. Though the procedure doesn’t make pregnancy impossible, it is best if you are not planning any future pregnancies. Ideally, you should be of stable weight, in good health, and a non-smoker if you’re considering abdominoplasty. A tummy tuck can be an excellent treatment to remove excess tissue, resculpting the abdomen to achieve a more taut, smooth contour. Men and women who have lost a significant amount of weight typically benefit from the procedure, as weight loss tends to leave behind loose, inelastic skin around the waist and abdomen. Your midsection may look out of proportion with the rest of your body, a common problem following pregnancy or substantial weight loss. If you are concerned about the loose skin and fat surrounding your midsection, you may be a good candidate for this procedure. ![]() ![]() Often utilized as a combination approach to address an expanded waistline, liposuction and excision are conducted during a tummy tuck to produce a tauter, more contoured abdomen.Īm I a Good Candidate for Tummy Tuck Surgery? Surgical excision is used to remove excess skin, while liposuction targets fat. The techniques used during the tummy tuck procedure - liposuction and surgical excision - are common to many body contouring techniques. During surgery, excess skin and fat are removed, and the muscles of the abdominal wall are repaired. Also referred to as “abdominoplasty,” the procedure may be part of a comprehensive post-bariatric body contouring plan. Neal Goldberg is proud to offer tummy tuck surgery at his plastic surgery practice.Ī tummy tuck is designed to address excess abdominal skin and loose tissue after pregnancy or major weight loss. If you want to improve the appearance of your abdomen, Dr. ![]()
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![]() On the road, though, it's the electric car that feels quicker, at least in day-to-day driving. If you did a drag race using launch control, the 760i would almost certainly prove the zippier car. On paper, the 760i has an advantage: it weighs about 900 pounds less. It may not be traditionally handsome, but when people see that front end in their mirror, they'll know to get the hell out of the way.Īs you might have noticed, both the V8-powered and the electrically motivated 7ers make almost identical power figures. ![]() ![]() Above all else, it's imperious: in the matte black of my electric-powered i7 tester, the face exudes serious Darth Vader vibes. It looks more proportionate and resolved than the 4 Series and M3 / M4 its grille seems right-sized, and the flanks and roofline bear a slight resemblance to the Rolls-Royce Ghost. Still, once you spend a little time with it.well, it never looks beautiful, but you start to appreciate how unabashedly bold it is. (Adding to that is its sheer size the front end is so tall and blocky, I kept subconsciously expecting an SUV when I caught a glimpse out of the corner of my eye.) The rear, meanwhile, defies convention by protruding its lower bumper way out, almost as though trying to imitate James William Bottomtooth III. The front fascia legitimately shocks at first, with its unexpected angles and sharp-eyed lights - especially in lighter colors that draw a greater contrast with the blacked-out center portion. It shouldn't come as a surprise at this point that a new BMW is far from conventionally attractive.but the new 7 Series manages to stand out even from the other new cars found in Bimmer showrooms. We probably should get that out of the way, shouldn't we. For all intents and purposes, however, they're the same car: the 2023 7 Series. So, for the 2023 model year, BMW has rolled out not one but two new full-size range-topping luxury sedans - one powered by gasoline, the other by electricity. ![]() Whenever an all-new one of these arrives, it's a big deal - and that's even more true today, when companies are under immense pressure to electrify and future-proof their lineups but not abandon the customers who still love their big gas-powered beasties. Mercedes-Benz may have pioneered this segment with the S-Class, but for the last few decades, rivals BMW and Audi have endeavored to keep pace with the 7 Series and A8, respectively - all of which possess similar qualities of supple ride, prodigious power, top-tier tech and enough legroom to please a giraffe. America has largely given up on this segment, and Japan and England have slashed back on it as well (unless you're looking to spend the really big bucks on a Bentley or Rolls-Royce), but the Germans are still battling it out with their big, imposing uberraketenschlitten. Sedans may not have the market share they used to, but there's one market segment where they still carry plenty of cache: the large-and-in-charge luxury market. ![]() ![]() Talking about her educational background, she graduated from high school at Beauty College located in England. Jasmine Monjack is a British nationality holder. What ethnicity is Jasmine Monjack? Nationality Moreover, Jasmine has a younger sister, whose identity is not revealed yet. She died on December 20, 2009, after pneumonia, iron-deficiency anemia, and a drug overdose. Likewise, her stepmother, Brittany Murphy, was a talented singer and professional American actress best remembered for portraying Tai Frasier in the adolescent film Clueless. ![]() Marica Newman is the name of Jasmine’s mother. Learn more about Simon and Brittany’s relationship and respective deaths by catching What Happened, Brittany Murphy? on HBO Max beginning October 14.Also, her mother worked as a housewife. It was said that he was “sending the money to lawyers as well as someone in Europe for some sort of settlement.” ![]() This time, he didn’t get off so easy and had to pay $470,000, the Post’s records show, and to make matters worse, Simon was also evicted from at least four separate homes over the course of almost a decade.Īdditionally, TMZ reported that Simon’s loved ones found thousands of dollars in wire transfers, with one single transfer amounting to $48,000. According to the New York Post, the following year, Simon found himself being sued by a mortgage firm for nearly half a million dollars. Simon was arrested in Virginia for credit card fraud and theft, according to the New York Post. He didn’t leave my mum anything at all when he died, no money at all.” He had messy legal and financial issues When I was with my dad, I saw his money, but not when he left. “He moved abroad and I didn’t speak to him for ages. “My parents broke up when I was 2 so I don’t remember them ever being a couple, but my dad lived in England when I was younger,” the then-18-year-old told the outlet, mentioning that she last saw her father when she was 7. She said she didn’t have a close relationship with her father but was deeply connected to her grandmother, Simon’s mom. Simon’s daughter, Jazmyn, spoke to the Daily Mail UK in 2013 when more rumors and investigations around his death were circulating. “I said, ‘Simon, I’ve made it to…’ and before I could get that sentence out, he hung up on me,” said Elizabeth in the series. According to People, Elizabeth revealed in the documentary that once she became pregnant, Simon wanted her to give birth in New York-he bought her a flight and she waited for her fiancé in the city. One of the women was Elizabeth Ragsdale, Simon’s former fiancée. Apparently, the communications revealed that Simon had both a son and a daughter by separate women. Simon’s mother, brother, and therapist found emails from two women asking him for child support. Upon Simon’s death, TMZ reported that three people close to him went through his laptop. He and Brittany began seeing each other shortly after his divorce was final. ![]() “He made sure no one could get to her.” Another teaser showed someone saying, “Every single word out of his mouth was a lie.” Now that What Happened, Brittany Murphy? is available beginning this week on HBO Max, here is everything we know about Simon and his marriage to Brittany.īefore dating Brittany, Simon was previously married to an English woman named Simone Bienne from 2001 to 2006. “Simon took her away,” said actor Lisa Rieffel, a dear friend of Brittany’s. Interviews in the trailer offered similar sentiments. Director of the docuseries Cynthia Hill told Peoplethat Monjack “was a disturbed individual who was used to conning people and Brittany was one of his last victims.” She continued, “There was a pattern of behavior that became very obvious the more research that we did.” More than a decade later, new unsettling and disheartening details about her passing have emerged in the two-part HBO Max documentary What Happened, Brittany Murphy?-a lot of which apparently involve her husband, Simon Monjack, his questionable past, and the couple’s marriage.įYI, Simon certainly wasn’t regarded by others as a good fit for Brittany-to put it gently. Ultimately, medical examiners at the Los Angeles coroner’s office ruled Brittany’s death an accident. Countless rumors circled Brittany’s death, which is said to have been caused by a host of issues like untreated pneumonia, anemia, and drug intoxication (from legal substances such as over-the-counter medicine and prescriptions). When news broke in 2009 that beloved Clueless actor Brittany Murphy died in her West Hollywood home, the world mourned the 32-year-old star. ![]() ![]() ![]() ![]() OPTIONAL OpenGL Tweak: If you're running Nvidia Proprietary drivers, there's a good chance you can gain even more performance. wine folder) use the commands listed in step 5. If you have to run Windows 7 (for instance, Overwatch is also installed in your. MAJOR BUG: Steam will be unpredictable if you run Wine with a Windows 7 prefix and without "-no-cef-sandbox." Windows XP prefix and the "-no-cef-sandbox" launch argument are MANDATORY to run Steam. However, I must stress that the game is still playable. * All graphical glitches from the OSX version will carry over since it's the same OpenGL renderer. If you run the game in full screen, you risk not being able to return to the desktop. * Intermittent cursor issues switching program focus (Overwatch has these issues as well, not isolated to just Subnautica) * FPS counter in windowed mode/certain resolutions (same issue as on OSX) * Debug GUIs (in game F1 and F3 menus are blank) if your Wine prefix is Windows XP and/or you forgot to install the corefonts from winetricks (optional) Minimize or close your Steam window as rendering resources could be saved when Wine doesn't have to render it. You can use the launch argument "-popupwindow" to enable rendering as a borderless window, but be aware that Linux is still relatively rusty when it comes to multi-monitor support so there's a chance it could show up on the wrong screen.ġ2. Launch Subnautica and enjoy the game at nearly native performance on Linux! I highly recommend bringing the game out of full-screen in case the game crashes, as it would be easier to recover if the game is windowed. Newer Nvidia Proprietary Drivers will work with "-force-glcore45", which is OpenGL 4.5.ġ1. (VERY IMPORTANT) add "-force-glcore" or "-force-opengl" to your launch options by right clicking the game under Properties > Launch Options. (I must stress, everytime you launch Steam, that launch argument is MANDATORY.) Log into Steam.ġ0. After installing Steam, In Terminal, type "wine" then a space then go to your ".wine" folder (You may have to enable seeing hidden files in your Home folder) C Drive under Program Files (x86)/Steam and drag Steam.exe into the Terminal and (VERY IMPORTANT) add the mandatory "-no-cef-sandbox" argument at the end as a launch argument and press enter. (Download the EXE, type "wine" in Terminal then add a space, and drag the file into the terminal then press enter.)Ĩ. Use Wine to install Windows Steam using the Steam Setup EXE for Windows. ![]() Trust me, this impacts performance greatly.)ħ. To prevent this, open a Terminal and type "sudo nano /etc/environment" (if nano is not installed, install it via apt-get or dnf) Add a line below "PATH=." and fill with "WINEDEBUG=-all,fixme-all" and press Ctrl X then Y, then Enter. (VERY IMPORTANT FOR PERFORMANCE) Because Wine Staging is an experimental version of Wine, it will print debug messages like crazy. Wine reg.exe ADD "HKEY_CURRENT_USER\Software\Wine\AppDefaults\steamwebhelper.exe" /v "Version" /t "REG_SZ" /d "winxp64" /fĦ. Wine reg.exe ADD "HKEY_CURRENT_USER\Software\Wine\AppDefaults\Steam.exe" /v "Version" /t "REG_SZ" /d "winxp64" /f (VERY IMPORTANT) Run these two commands in Terminal: Install winetricks via apt or dnf and run "winetricks corefonts"ĥ. (VERY IMPORTANT) In the "Staging" tab, turn on "Enable_CSMT", "Enable_VAAPI" and "Hide Wine version from applications". In Terminal, run "winecfg" AS A STANDARD USER. Install the latest Wine Staging for your distribution: Ģ. Thanks also for Mike Kronenberg for WineBottler and making Teach2000 a prefix.Just tested Subnautica (latest stable build 54762) using the latest Wine Staging on Ubuntu 16.04 LTS and it totally works! Here are the instructions:ġ. Thanks to the community of Wine for creating it and fixing our reported bugs. Double click and Teach2000 starts on your Mac!!.Program contains the new Mac Teach2000 now (example Teach2000Mac.app).The location to save Teach2000 is C:\Program files\Teach2000. Follow the installation instructions of the Teach2000 setup.Enter the filename for Teach2000 (example 'Teach2000Mac' and choose 'Save'.Click on the left side on the button 'Install Predefined Prefixes'. Click on the downloaded DMG file and move Wine and WineBottler to the application folder. Install WineBottler like every other application.We tested with 'WineBottlerCombo_1.1.44.dmg'. In order to start Teach2000 on your Mac you have to do the following: WineBottler is an extra layer that makes an application think it is running on Windows, while behind the curtains Mac OS X is running. Teach2000 for Mac OS X Teach2000 for Mac OS Xĭo you own a MacBook or another Apple computer? And is the processor Intel based? Than we have good news, because you can install Teach2000 on your computer. ![]() ![]() When ranking the best free accounting software, we considered these factors to help you find the best software for your business. When she’s not trying out the latest tech or travel blogging with her family, you can find her curling up with a good novel. For over a decade, she’s helped small business owners make money online. Kathy Haan, MBA is a former financial advisor-turned-writer and business coach. Our accounting reports are easy to use and show monthly or yearly comparisons, so you can easily identify cash flow trends. Should your needs extend beyond that, you’ll need to upgrade to one of its premium plans. You can only link one bank account and view basic reports with its starter option. ![]() The program’s features you can access with a free plan are restricted to the point that it might be easy to outgrow. We considered the software’s general accounting features, banking, A/P, A/R, tax, and reporting features. ![]() We evaluated the best free accounting software in terms of general features and whether they have the basic functions of paid solutions, such as bank feeds and bank reconciliations.Wave is one of the best options available for sole proprietors, freelancers and small businesses.Often, marketing promises don’t always match reality, so reviews can help determine whether a software lives up to its claims. We also looked at customer reviews to see what users are saying about the software. Any connections between you, your bank accounts, and Wave are protected by 256-bit SSL encryption. ![]() ![]() You also don’t have to wait for all students to complete tasks so you will probably be able to have a shorter school day and still cover the same curriculum. Homeschooling parents don’t have to waste time on administrative tasks, such as roll call, preparing 30 students for lunch, or allowing time for students to move from one classroom to the next between subjects. A homeschool daily schedule does not have to be as long as a public or private school day. When people refer to a home school schedule, they are referring to a typical daily schedule. Set the weekly schedule that will work best for you and your family. For instance, if a parent works Wednesday and Thursday, you change your school week to Friday to Tuesday. You can change the school days to work for your family. ![]() One of the advantages of homeschooling is that Monday to Friday doesn’t have to be your weekly routine. Decide how many breaks and days off you will allow for. Pick a start date and count the days from the start date until you have reached the number of study days you want to complete. Check what your state’s requirements are. A school year usually has 180 days which works out to four quarters of 9 weeks each, or two semesters of 18 weeks, or 36 weeks. Your yearly calendar is the first thing that you’ll want to decide on. Let’s break down homeschool schedules into some manageable portions for planning an effective schedule: Yearly Schedule So, how do you make a home-school schedule? The best thing about homeschooling is the flexibility. Some parents follow the standard school timetable, others homeschool year-round, while some take off time whenever they feel their kids need a break. Homeschoolers have total freedom over the framework of their school year. Suitable time frame for effective learning (see time blocking).Subjects you will study and gather all the material required.Before you plan an effective schedule you should decide on your: ![]() A homeschool schedule for older children is different than preschool and kindergarten children. Your homeschooling schedule will depend a lot on the age of your child. With the Word version, you can delete lines, change the times, add columns or lines and make pretty much any change you want. ![]() If you prefer an editable homeschool schedule template then select the Word version. If you want to use any of the templates as-is then download the homeschool schedule pdf version. Each of the templates is offered as an image, a Microsoft Word file, or an editable PDF file. ![]() ![]() ![]() One of the stories in the book is about the decision for Michael Jordan to walk away from basketball baseball - immense courage, right? Think of the amount of people that told him he couldn’t make it. It’s more like a day-in-and-day-out ‘What do you do?’ One of the places we struggle with the most is: If courage is rare, courage in pursuit of the right thing is rarer, the virtues are interrelated. I asked Ryan where he thought people lack courage the most - is it just being honest with themself? Is it lying to other people? Is it not standing up for what’s right? ![]() ![]() We often think of courage physically but seldom contemplate moral courage - something Ryan believes is even more challenging and rare these days. I’m very excited to talk to my good friend Ryan, so let’s jump straight in! Courage in Today’s World in Today’s World Ryan also owns a bookstore called The Painted Porch and hosts the podcast The Daily Stoic. Despite having grown up in Sacramento, Ryan now spends much of his time on a ranch outside Austin, Texas, where he writes and works between raising cattle, donkeys, and goats. Ryan’s books have a prominent following, including some NFL coaches, world-class athletes, TV personalities, political leaders, and others worldwide. Ryan had a successful marketing career at American Apparel before finding a creative agency called Brass Check, which has advised clients like Google, ONNIT, and Complex, and many prominent bestselling authors, including Neil Strauss, Tony Robbins, and Tim Ferriss. When Ryan was 19 years old, he dropped out of college to apprentice under Robert Greene, author of The 48 Laws of Power. Together, they have sold two million copies and been translated into 30 languages. As a best-selling American author, Ryan’s incredible books include The Obstacle Is the Way, Ego Is the Enemy, The Daily Stoic, and Stillness Is the Key. Ryan Holiday is one of the world’s foremost writers on ancient philosophy and its place in everyday life. Ryan’s now written a new book called Courage Is Calling: Fortune Favors the Brave, and in this episode, we discuss how fear is actually a good thing for us, why people struggle to have courage and how to overcome that in your life, how thinking about your own mortality can help us rather than hurting us, the biggest lessons we can learn from stoicism when it comes to finding peace, wealth, and developing discipline, and so much more. Ryan Holiday wanted to write what he wished other blogs would talk about more often: life, how to be self-critical and self-aware, humility, philosophy, reading, learning, research, and strategy. My guest today started his journey to embody ancient wisdom as a blog nearly ten years ago to help him along his journey of self-education. Have you ever heard people talk about “ancient wisdom” but then wondered how it applies to you today? ![]() ![]() ![]() in Electrical Engineering from Stanford, and a J.D. ![]() in Electrical Engineering from Caltech, an M.S. Prior to joining Evonik, Tom has held roles in venture capital investing, startup patent strategy, and applied physics research - providing a broad set of experiences to draw upon in support of Evonik’s investments. Tom has been actively involved in the technology community in the valley for over a decade. Tom Gwinn is an Investment Manager at Evonik Venture Capital (EVC) based in Silicon Valley. Tak received a BS with Honors in Engineering and Applied Science from the California Institute of Technology, an MD from the University of California, Irvine, and an MBA from Harvard Business School. Tak has held various corporate and business development leadership roles at Edwards Lifesciences in the Heart Valve Therapy Division and Advanced Medical Optics (acquired by Johnson & Johnson). Prior to Merieux and Lexington, Tak was VP of Business Development for the Global Surgical Division at Bausch & Lomb, and was responsible for all business development efforts in the ophthalmic surgical division. Tak also co-founded Lexington Medical, a commercial-stage medical device startup in the gastrointestinal surgery space. Prior to NEA, Tak was a Venture Partner at Merieux Development Venture Fund where he led all phases of investment for healthcare startups, including sourcing, diligence and investment approvals. He focuses on medical device investments. Tak joined NEA in 2018 and is currently a Partner on the healthcare team. The audience is welcome to bring many questions to this rare and unique opportunity and engage live. The format of this event will focus on a moderated panel discussion focusing on the current status, short-term, and longer-term outlook of the institutional investment landscape. In this unique 3DHEALS virtual event, we would like you to meet some of the VCs and angel investors behind the scene and learn more about the medical device and biotechnology investment environment under the current macroeconomy. Since April 20th, 2018, 3DHEALS has hosted numerous online and offline Pitch3D sessions regularly, introducing 30+ startups from all over the world to institutional investors who are interested in healthcare 3D printing, bioprinting, and adjacent fields including AI and cybersecurity (within 3D printing), 3D scanning, VR/AR, 3D Visualization, synthetic materials, and regenerative medicine. Our goal is to save the founders and selected institutional investors time to meet each other at the right time along the company’s journey at zero cost to either side. “A lot of people who raised their first fund or their second fund will not be able to raise their third.One of the most exciting missions at 3DHEALS is discovering early-stage startups, meeting the founders, and helping these companies with fundraising through our Pitch3D program. “There’s just not going to be enough capital going into the asset class,” she said. “We’re not sure that venture capital is an asset class that will endure in the next few decades at the height that we experienced in the last few years,” Ho said, later predicting a “drastically lower number of investors and investment firms in the next decade.” Venture capital funding in the first quarter was down over 50% year-on-year, according to Crunchbase-and that’s even counting Microsoft’s bumper $10 billion investment in A.I. interest rates and a lower appetite for risk have punctured the tech bubble that developed over the past decade. ![]() Venture investment, both overall and in health startups specifically, at least doubled every year between 20.īut higher U.S. The surge in venture funding in digital health, Ho noted, tracked the surge in venture funding more broadly. ![]() “It’s going to be a world of hurt for the next couple of years,” Aike Ho, a general partner at ACME Capital, said during a panel about venture investments in digital health at Fortune’s Brainstorm Health conference in Los Angeles on Tuesday. ![]() ![]() ![]() Since TCM isn't cached and accessible at the same speed as the processor and cache, it could be conceptually described as "addressable cache". Other than CPU cache, TCM is the fastest memory in an ARM Cortex-M microcontroller. Tightly-Coupled Memory (TCM): Low-latency (zero wait state) SRAM that can be used to hold the call stack, RTOS control structures, interrupt data structures, interrupt handler code, and speed critical code.It supports up to sixteen different regions, each of which can be split further into equal-size sub-regions. Memory Protection Unit (MPU): Provides support for protecting regions of memory through enforcing privilege and access rules.Some Cortex-M0 and Cortex-M0+ microcontrollers have bit-band. Though the bit-band is optional, it is less common to find a Cortex-M3 and Cortex-M4 microcontroller without it. In particular, individual bits can be set, cleared, or toggled from C/C++ without performing a read-modify-write sequence of instructions. This allows every individual bit in the bit-band region to be directly accessible from a word-aligned address. For example, writing to an alias word will set or clear the corresponding bit in the bit-band region. Bit-Band: Maps a complete word of memory onto a single bit in the bit-band region.If a Cortex-M33/M35P/M55/M85 microcontroller has the Security Extension option, then it optionally can have two SysTicks (one Secure, one Non-secure). Though the SysTick timer is optional for the M0/M0+/M1/M23, it is extremely rare to find a Cortex-M microcontroller without it. When present, it also provides an additional configurable priority SysTick interrupt. SysTick timer: A 24-bit system timer that extends the functionality of both the processor and the Nested Vectored Interrupt Controller (NVIC).Some of the silicon options for the Cortex-M cores are: To determine which components have been included in a particular ARM CPU chip, consult the manufacturer datasheet and related documentation. This allows the manufacturer to achieve custom design goals, such as higher clock speed, very low power consumption, instruction set extensions (including floating point), optimizations for size, debug support, etc. In this form, they have the ability to perform architectural level optimizations and extensions. Integrated Device Manufacturers (IDM) receive the ARM Processor IP as synthesizable RTL (written in Verilog). To all licensees, Arm provides an integratable hardware description of the ARM core, as well as complete software development toolset and the right to sell manufactured silicon containing the ARM CPU. Arm offers a variety of licensing terms, varying in cost and deliverables. Cortex-M have become a popular replacements for 8-bit chips in applications that benefit from 32-bit math operations, and replacing older legacy ARM cores such as ARM7 and ARM9.ĪRM Limited neither manufactures nor sells CPU devices based on its own designs, but rather licenses the processor architecture to interested parties. Though 8-bit microcontrollers were very popular in the past, Cortex-M has slowly been chipping away at the 8-bit market as the prices of low-end Cortex-M chips have moved downward. A full-fledged operating system does not normally run on this class of processor. The main difference from the Cortex-A core is that there is no memory management unit (MMU). Cortex-M cores are commonly used as dedicated microcontroller chips, but also are "hidden" inside of SoC chips as power management controllers, I/O controllers, system controllers, touch screen controllers, smart battery controllers, and sensors controllers. ![]() The ARM Cortex-M family are ARM microprocessor cores which are designed for use in microcontrollers, ASICs, ASSPs, FPGAs, and SoCs. See also: ARM architecture and List of ARM cores A floating-point unit (FPU) option is available for Cortex-M4 / M7 / M33 / M35P / M55 / M85 cores, and when included in the silicon these cores are sometimes known as "Cortex-MxF", where 'x' is the core variant. The Cortex-M family consists of Cortex-M0, Cortex-M0+, Cortex-M1, Cortex-M3, Cortex-M4, Cortex-M7, Cortex-M23, Cortex-M33, Cortex-M35P, Cortex-M55, Cortex-M85. Though they are most often the main component of microcontroller chips, sometimes they are embedded inside other types of chips too. These cores are optimized for low-cost and energy-efficient integrated circuits, which have been embedded in tens of billions of consumer devices. The ARM Cortex-M is a group of 32-bit RISC ARM processor cores licensed by ARM Limited. 24 MHz ARM Cortex-M3 microcontroller with 16 KB flash memory, 4 KB RAM. ![]() ![]() Young children of both sexes are very susceptible to theĪttack of Yaws. Too small to attract attention or as big as a rupee resisting all local "The primary lesion is almost always single and often occursĪt the site of an existing ulcer or bruise. The following description and the above photosĪre from his records of the disease(unpublished,1936). Was an assistant surgeon in Kadakkal, a small town in what is now Of the princely state of Travancore in South India. In the 1930s yaws was an endemic disease in the hilly areas Late manifestations include bone,Ĭartilage and joint infections in the form of granulomas (gummata) orĭestructive lesions which cause deformities. Primary stage is characterised by a single skin lesion ("mother yaw")įollowed by multiple disseminated lesions. Yaws is chronic and manifests in primary and secondary stages. It is one of the non-venereal treponematoses, the others being pinta and endemic syphilis.2 The endemic treponematoses are transmitted by direct contact, acquired during childhood and can cause severe late manifestations years after initial infection. pertenue, a spirochaete closely related to Treponema pallidum, the causative agent of syphilis. Except as otherwise required by law, Atara Bio disclaims any intention or obligation to update or revise any forward-looking statements, which speak only as of the date hereof, whether as a result of new information, future events or circumstances or otherwise.Yaws is a disease caused by Treponema pallidum subsp. For example, forward-looking statements include statements regarding reporting of preliminary top-line data by the end of the fourth quarter of 2015 and the evaluation of the data to guide future development of PINTA 745.These forward-looking statements are subject to other risks and uncertainties, including those discussed under the heading "Risk Factors" in Atara Bio's quarterly report on Form 10-Q filed with the Securities and Exchange Commission (SEC) on August 6, 2015, including the documents incorporated by reference therein and subsequent filings with the SEC. Because such statements deal with future events and are based on Atara Bio's current expectations, they are subject to various risks and uncertainties and actual results, performance or achievements of Atara Bio could differ materially from those described in or implied by the statements in this press release. This press release contains or may imply "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. T-cell product candidates include EBV-CTL, CMV-CTL and WT1-CTL. Molecularly targeted product candidates include PINTA 745, STM 434 and ATA 842, members of the TGF-beta family of proteins that target myostatin and activin, and have demonstrated the potential to have therapeutic benefit in a number of clinical indications. Atara Bio's programs include molecularly targeted product candidates and T-cell product candidates. is a biopharmaceutical company focused on developing innovative therapies for patients with debilitating diseases. "Atara Bio is pleased to report the completion of enrollment to the PINTA 745 trial and looks forward to reviewing the data towards the end of this year," said Christopher Haqq, MD, Chief Medical Officer of Atara Bio.Ītara Biotherapeutics, Inc. The clinical trial was designed to provide proof of concept data for ESRD patients. The company believes that patients with PEW may benefit from the muscle-building demonstrated in earlier clinical trials and anti-inflammatory properties of PINTA 745 demonstrated in preclinical studies. ![]() PEW refers to a state of muscle wasting, inflammation and malnutrition that increases patients' risk for infections, cardiovascular disease and other complications. Atara Bio is conducting a Phase 2 trial in patients with ESRD who are also suffering from PEW at six US-based sites. PINTA 745 is a peptibody that binds myostatin and inhibits its corresponding signal transduction, thereby blocking the negative regulation of skeletal muscle growth. The company expects to report preliminary top-line data by the end of the fourth quarter of 2015. ![]() (Nasdaq:ATRA), a biopharmaceutical company with a focus on developing innovative therapies for patients with debilitating diseases, today announced that it completed enrollment in its blinded, randomized, PINTA 745 Phase 2 clinical trial in End-Stage Renal Disease (ESRD) patients with Protein Energy Wasting (PEW). ![]() 31, 2015 (GLOBE NEWSWIRE) - Atara Biotherapeutics, Inc. Preliminary Top-Line Data Expected by the End of the Fourth Quarter of 2015 ![]() |
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